Browsing Brody School of Medicine by Author "Wang, Tao"
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American Ginseng Modifies 137Cs-Induced DNA Damage and Oxidative Stress in Human Lymphocytes
Lee, Tung-Kwang; O'Brien, Kevin F.; Wang, Weidong; Sheng, Chao; Wang, Tao; Johnke, Roberta M.; Allison, Ron R. (East Carolina University, 2009-01-01)The multifold bioactive medicinal properties of ginseng have been closely linked to its antioxidative ability, which is related to its ginsenoside content. Since the key mechanism of radiation-induced cell death and tissue ... -
delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
Zeng, Yan; Abdallah, Agustin; Lu, Jian-Ping; Wang, Tao; Chen, Yan-Hua; Terrian, David M.; Kim, Kwonseop; Lu, Qun (East Carolina University, 2009-03-10)Background: delta-Catenin is a unique member of delta-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, delta-catenin is upregulated in human prostatic adenocarcinomas, ... -
Effect of North American Ginseng on 137Cs-induced Micronuclei in Human Lymphocytes
Lee, Tung-Kwang; Wang, Weidong; O'Brien, Kevin F.; Roberta, Johnke; Allison, Ron R.; Diaz, Angelica; Wang, Tao (East Carolina University, 2008-12)To explore the radioprotective effect of a standardized North American ginseng extract (NAGE) on human peripheral blood lymphocytes (PBL), a micronuclei (MN) assay was conducted in PBL obtained from 12 volunteers. NAGE ... -
Identification of E2F1 as a positive transcriptional regulator for delta-catenin
Kim, Kwonseop; Oh, Minsoo; Ki, Hyunkyoung; Wang, Tao; Bareiss, Sonja; Fini, M. Elizabeth; Li, Dawei; Lu, Qun (East Carolina University, 2008-05-02)Delta-Catenin is upregulated in human carcinomas. However, little is known about the potential transcriptional factors that regulate delta-catenin expression in cancer. Using a human delta-catenin reporter system, we have ... -
Increased nucleotide polymorphic changes in the 5'-untranslated region of δ-catenin (CTNND2) gene in prostate cancer
Wang, Tao; Chen, Yan-Hua; Hong, Heng; Zeng, Yan; Zhang, Jiao; Lu, Jian-Ping; Jeansonne, Beverly; Lu, Qun (East Carolina University, 2009-01)Cancer pathogenesis involves multiple genetic and epigenetic alterations, which result in oncogenic changes in gene expression. δ-Catenin (CTNND2) is overexpressed in cancer although the mechanisms of its upregulation are ... -
Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Post-irradiation: A Study of 40 Cases
Lee, Tung-Kwang; O'Brien, Kevin F.; Wang, Weidong; Johnke, Roberta M.; Sheng, Chao; Benhabib, Sidi Mohammed; Wang, Tao; Allison, Ron R. (East Carolina University, 2010-05)Backgroundâ Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. As the diversity of IR applied in medicine, ...