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Now showing items 121-130 of 223
Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of cathecholamine synthesis and dehydration
(East Carolina University, 2007-10-22)
We used neuronal nitric oxide synthase (nNOS) gene knockout mice to study the effects of
catecholamines and neuronal nitric oxide on vasopressin expression in the hypothalamic
neurosecretory centers. nNOS gene deletion ...
Interaction of memantine with ethanol consumption and dopaminergic function in high ethanol preferring rats
(East Carolina University, 2009)
N-methyl-D-aspartate (NMDA) receptor antagonists have been reported to decrease ethanol consumption in rodents, but these drugs often produce adverse side effects. Memantine is a neuroprotective and low-affinity, ...
Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids
(East Carolina University, 2008-01-31)
Background: Spermatogenesis is comprised of a series of highly regulated developmental changes that transform the precursor germ cell into a highly specialized spermatozoon. The last phase of spermatogenesis, termed ...
Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cells
(East Carolina University, 2007-03-06)
The mechanisms underlying stem cell acquisition of a cardiac
phenotype are unresolved. We studied early events during the
acquisition of a cardiac phenotype by a cloned adult liver stem cell
line (WB F344) in a cardiac ...
Reporting and Concordance of Methodologic Criteria Between Abstracts and Articles in Diagnostic Test Studies
(East Carolina University, 2000-03)
OBJECTIVE: To evaluate the quality and concordance of methodologic criteria in abstracts versus articles regarding the diagnosis of trichomoniasis.
STUDY DESIGN: Survey of published literature.
DATA SOURCES: ...
The effect of brevenal on brevetoxin-induced DNA damage in human lymphocytes
(East Carolina University, 2005-11)
Brevenal is a nontoxic short-chain trans-syn polyether that competes with brevetoxin (PbTx) for the active site on voltage-sensitive sodium channels. The PbTxs are highly potent polyether toxins produced during blooms of ...
The Influence of Iron on Pseudomonas aeruginosa Physiology: A regulatory link between iron and quorum sensing
(East Carolina University, 2008-06-06)
In iron-replete environments, the Pseudomonas aeruginosa Fur (ferric uptake regulator) protein represses expression of two small regulatory RNAs encoded by prrF1 and prrF2. Here we describe the effects of iron and PrrF ...
Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery
(East Carolina University, 2008-12)
Context: Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity. Objective: The aim of the study was to investigate the effects of gastric bypass surgery and the ...
LOCAL ADMINISTRATION OF CARBON MONOXIDE INHIBITS NEOINTIMA FORMATION IN BALLOON INJURED RAT CAROTID ARTERIES
(2005)
Recent studies indicate that systemic induction of heme oxygenase-1 (HO-1), which oxidatively degrades heme into iron, biliverdin, and carbon monoxide (CO), or adenoviral-mediated gene transfer of HO-1 inhibits neointima ...
Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation
(2004-11-30)
A pharmaceutical composition effective for preventing and alleviating bronchoconstriction, lung allergy(ies) and inflammation comprises a surfactant and an oligonucleotide anti-sense to an adenosine receptor gene, flanking ...