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Intratracheal instillation of silver nanoparticles exacerbates cardiac ischemia/reperfusion injury in male sprague-dawley rats
(East Carolina University, 2014)
The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Exposure to particulate matter has been demonstrated to negatively influence cardiovascular health and expand myocardial ...
The agony of agonal respiration: is the last gasp necessary?
(East Carolina University, 2002-06)
Gasping respiration in the dying patient is the last respiratory pattern prior to terminal apnoea. The
duration of the gasping respiration phase varies; it may be as brief as one or two breaths to a
prolonged period of ...
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)
Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ...
Role of central cannabinoid receptor GPR18 in cardiovascular regulation
(East Carolina University, 2014)
The primary goal of this study was to characterize the role of GPR18 in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and elucidate the mechanisms involved in central GPR18 mediated hypotensive ...
Genetic and Structural Analysis of the Bacteroides Conjugative Transposon CTn341
(East Carolina University, 2005-04)
The genetic structure and functional organization of a Bacteroides conjugative transposon (CTn), CTn341, were determined. CTn341 was originally isolated from a tetracycline-resistant clinical isolate of Bacteroides vulgatus. ...
Genetic Organization and Iron-Responsive Regulation of the Brucella abortus 2,3-Dihydroxybenzoic Acid Biosynthesis Operon, a Cluster of Genes Required for Wild-Type Virulence in Pregnant Cattle
(East Carolina University, 2003-04)
Brucella abortus reportedly produces the monocatechol siderophore 2,3-dihydroxybenzoic acid (2,3-DHBA) in response to iron limitation. Nucleotide sequence analysis of the cloned DHBA biosynthesis locus from virulent B. ...
Exposure to Concentrated Coarse Air Pollution Particles Causes Mild Cardiopulmonary Effects in Healthy Young Adults
(East Carolina University, 2009-07)
Background: There is ample epidemiologic and toxicologic evidence that exposure to fine particulate matter (PM) air pollution [aerodynamic diameter ≤ 2.5 μm (PM2.5)], which derives primarily from combustion processes, can ...
Equitable rationing of highly specialised health care services for children: a perspective from South Africa.
(East Carolina University, 1999-06)
The principles of equality and equity, respectively in the Bill of Rights and the white paper on health, provide the moral and legalfoundations forfuture health care for children in South Africa. However, given extreme ...
DINITROBENZENES STIMULATE ELECTRON FLUX WITHIN NEURONAL NITRIC OXIDE SYNTHASE IN THE ABSENCE OF CALMODULIN
(2011)
Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide
(NO●) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding. The
present study focused on electron transfer ...
Special Concerns through an early pregnancy journey
(2016-06)
Nutrition and supplementation in the woman of reproductive age can have profound and lasting effects on her child’s health. Preconception planning for all women should include advice to begin folic acid supplementation at ...