Browsing Open Access by Title
Now showing items 380-399 of 866
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Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia
(2016-08-01)An attractive molecular target for novel anti-cancer therapies is the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway which is commonly deregulated in many types of cancer. Nevertheless, ... -
The heart healthy lenoir project-an intervention to reduce disparities in hypertension control: Study protocol
(2013-10-25)Background Racial disparities in blood pressure control are well established; however the impact of low health literacy (LHL) on blood pressure has garnered less attention. Office based interventions that are created with ... -
Hemodynamic-GUIDEd management of Heart Failure (GUIDE-HF)
(2019-04-25)In that study, incremental reductions in the PA pressures in the monitored arm were associated with both reduction in the frequency of HFH and improvements in health-related quality of life among patients with both preserved ... -
High major histocompatibility complex class I polymorphism despite bottlenecks in wild and domesticated populations of the zebra finch (Taeniopygia guttata)
(2015-12)Background: Two subspecies of zebra finch, Taeniopygia guttata castanotis and T. g. guttata are native to Australia and the Lesser Sunda Islands, respectively. The Australian subspecies has been domesticated and is now ... -
High throughput deep sequencing reveals the important roles of microRNAs during sweetpotato storage at chilling temperature
(2017-11-29)Sweetpotato (Impomoea batatas L.) is a globally important economic food crop with a potential of becoming a bioenergy and pharmaceutical crop. Thus, studying the molecular mechanism of tuberous root development and storage ... -
High-intensity exercise to promote accelerated improvements in cardiorespiratory fitness (HI-PACE): study protocol for a randomized controlled trial
(2019-08-08)Background: African Americans have a disproportionate prevalence and incidence of type 2 diabetes compared with Caucasians. Recent evidence indicates that low cardiorespiratory fitness (CRF) level, an independent risk ... -
Histological and immunohistochemical features of the spleen in persistent polyclonal B-cell lymphocytosis closely mimic splenic B-cell lymphoma
(2012-08-19)Persistent polyclonal B-cell lymphocytosis (PPBL) is rare and intriguing hematological disorder predominantly reported in young to middle- aged smoking women. It is characterized by persistent moderate polyclonal B-cell ... -
HIV screening and awareness survey for pregnant women in a remote area in Xinjiang Uyghur autonomous region of China
(2011-11-30)The number of people infected with human immunodeficiency virus (HIV) in China has increased in recent years. HIV screening for pregnant women was performed in a remote area in Xinjiang, as an effort to promote universal ... -
The home environment and childhood obesity in low-income households: Indirect effects via sleep duration and screen time
(2014-11-09)Background: Childhood obesity disproportionally affects children from low-income households. With the aim of informing interventions, this study examined pathways through which the physical and social home environment may ... -
Horizontal and vertical self-paced saccades as a diagnostic marker of traumatic brain injury
(2019-07-25)Eye tracking tests to measure horizontal and vertical saccades as a proxy for neural deficits associated with traumatic brain injury (TBI) were evaluated in the present study. Methodology: A total of 287 participants ... -
Horizontal gene transfer of epigenetic machinery and evolution of parasitism in the malaria parasite Plasmodium falciparum and other apicomplexans
(2013-02-11)The acquisition of complex transcriptional regulatory abilities and epigenetic machinery facilitated the transition of the ancestor of apicomplexans from a free-living organism to an obligate parasite. The ability to control ... -
Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion
(2019-06)Fibrinogen is an essential part of the blood coagulation cascade and a major component of the extracellular matrix in mammals. The interface between fibrinogen and bacterial pathogens is an important determinant of the ... -
How many steps/day are enough? For older adults and special populations
(2011-07-28)Older adults and special populations (living with disability and/or chronic illness that may limit mobility and/or physical endurance) can benefit from practicing a more physically active lifestyle, typically by increasing ... -
How Pre-tenure and Tenured Faculty Can Engage Undergraduates in Publishable Research
(2019-02-06)Differences in career stage may influence work stress and job satisfaction (Olsen and Crawford, 1998), which in turn can impact attitudes about recruiting, managing, and mentoring undergraduates in publishable research ... -
HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I
(2019-06-28)Adult T-cell Leukemia (ATL) is a lymphoproliferative disease of CD4+ T-cells infected with Human T-cell Leukemia Virus type I (HTLV-1). With the exception of allogeneic hematopoietic stem cell transplantation, there are ... -
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP
(2012-03-19)The homologous cellular coactivators p300 and CBP contain intrinsic lysine acetyl transferase (termed HAT) activity. This activity is responsible for acetylation of several sites on the histones as well as modification of ... -
A Hydroclimatological Analysis of Precipitation in the Ganges–Brahmaputra–Meghna River Basin
(2018-09-29)Understanding seasonal precipitation input into river basins is important for linking large-scale climate drivers with societal water resources and the occurrence of hydrologic hazards such as floods and riverbank erosion. ... -
Hypoxia and Hypoglycemia synergistically regulate mRNA stability
(2017-07)Ischemic events, common in many diseases, result from decreased blood flow and impaired delivery of oxygen and glucose to tissues of the body. While much is known about the cellular transcriptional response to ischemia, ... -
Hypoxia inducible factor-1α-dependent epithelial to mesenchymal transition under hypoxic conditions in prostate cancer cells
(2016)Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death. Hypoxia is an environmental stimulus that plays an important role in the development and cancer progression ...