Browsing Open Access by Title
Now showing items 441-460 of 866
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Inhibition of vascular smooth muscle growth via signaling crosstalk between amp-activated protein kinase and camp-dependent protein kinase
(2012-10-29)Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings from our lab and others support growth control ... -
Insulin/IGF1-PI3K-dependent nucleolar localization of a glycolytic enzyme – phosphoglycerate mutase 2, is necessary for proper structure of nucleolus and RNA synthesis
(2015)Phosphoglycerate mutase (PGAM), a conserved, glycolytic enzyme has been found in nucleoli of cancer cells. Here, we present evidence that accumulation of PGAM in the nucleolus is a universal phenomenon concerning not ... -
Integrated transcriptome, small RNA and degradome sequencing approaches provide insights into Ascochyta blight resistance in chickpea
(2018-10-16)Ascochyta blight (AB) is one of the major biotic stresses known to limit the chickpea production worldwide. To dissect the complex mechanisms of AB resistance in chickpea, three approaches, namely, transcriptome, small RNA ... -
Interactions of a Dopamine D1 Receptor Agonist with Glutamate NMDA Receptor Antagonists on the Volitional Consumption of Ethanol by the mHEP Rat
(2013-03-26)Stimulation of the dopamine D1 receptor is reported to cause the phosphorylation of DARPP-32 at the thre34 position and activates the protein. If intracellular Ca2+ is increased, such as after activation of the glutamate ... -
Interdisciplinary Diabetes Care: A New Model for Inpatient Diabetes Education
(2015-11)A patient-centered interdisciplinary diabetes care model was implemented at Vidant Medical Center in Greenville, N.C., a 909-bed tertiary care teaching hospital, for the purpose of providing all patients with diabetes clear ... -
International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing
(2019-01-07)In this Position Statement, the International Society of Sports Nutrition (ISSN) provides an objective and critical review of the literature pertinent to nutritional considerations for training and racing in single-stage ... -
Interventions to improve sarcopenia in cirrhosis: A systematic review
(2019-01-26)BACKGROUND: Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it ... -
intraoperative Radiotherapy for Breast Cancer
(2017-12-22)Intraoperative radiotherapy (IORT) for early stage breast cancer is a technique for partial breast irradiation. There are several technologies in clinical use to perform breast IORT. Regardless of technique, IORT generally ... -
Intravenously delivered graphene nanosheets and multiwalled carbon nanotubes induce site-specific Th2 inflammatory responses via the IL-33/ST2 axis
(2013-05-03)Carbon-based nanomaterials (CBN), such as graphene nanosheets (GNS) and multiwalled carbon nanotubes (MWCNT), have been proposed for potential nanomedicine applications such as biomedical devices and carriers for drug ... -
Introducing the global medical community to the information presented at local scientific conferences through nephrology blogs
(2012-12-14)An increasing number of healthcare providers author medical blogs (bloggers) to educate the public and fellow physicians. Traditionally, many bloggers have assumed that readers are most interested in information presented ... -
Introduction: Biology and the Idea of Culture
(2014)This chapter analyses Frankenstein's dramatization of the costs and consequences of the drive for transcendence in terms of humanist culture's anxieties about human and nonhuman identities in capitalist production. The ... -
Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy
(2011-07-01)Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs is clearly important as these are frequently used therapeutic approaches. A signaling pathway often involved in chemo- and ... -
Is content really king? An objective analysis of the public's response to medical videos on YouTube
(2013-12-18)Medical educators and patients are turning to YouTube to teach and learn about medical conditions. These videos are from authors whose credibility cannot be verified & are not peer reviewed. As a result, studies that have ... -
Is field of study or location associated with college students' snacking patterns?
(2012)Objective. To compare on- and off-campus snacking patterns among college students pursuing degrees in health-related fields (HRFs) and nonhealth-related fields (NHRFs). Materials and Methods. Snack frequency questionnaire, ... -
Is Motorized Treadmill Running Biomechanically Comparable to Overground Running? A Systematic Review and Meta-Analysis of Cross-Over Studies
(2019-12-04)Background Treadmills are often used in research, clinical practice, and training. Biomechanical investigations comparing treadmill and overground running report inconsistent findings. Objective This study aimed at comparing ... -
Is the genetic landscape of the deep subsurface biosphere affected by viruses?
(2011-11-09)Viruses are powerful manipulators of microbial diversity, biogeochemistry, and evolution in the marine environment. Viruses can directly influence the genetic capabilities and the fitness of their hosts through the use of ... -
Is there a metabolic program in the skeletal muscle of obese individuals?
(2011-04-26)Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are ... -
Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
(2019-07-05)Background Compared to conventional chemotherapy, Immune checkpoint inhibitors (ICI) are known to have a distinct toxicity profile commonly identified as immune-related adverse events (irAEs). These irAEs that are believed ... -
Isolation and molecular identification of endophytic diazotrophs from seeds and stems of three cereal crops
(2017-10-30)Ten strains of endophytic diazotroph were isolated and identified from the plants collected from three different agricultural crop species, wheat, rice and maize, using the nitrogen-free selective isolation conditions. The ... -
It’s not what you expect: feedback negativity is independent of reward expectation and affective responsivity in a non-probabilistic task
(2017-03)ERP studies commonly utilize gambling-based reinforcement tasks to elicit feedback negativity (FN) responses. This study used a pattern learning task in order to limit gambling-related fallacious reasoning and possible ...