Browsing Open Access by Title
Now showing items 812-831 of 866
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Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers
(2019-01-10)Characterization of small oligomers formed at an early stage of amyloid formation is critical to understanding molecular mechanism of pathogenic aggregation process. Here we identifed and characterized cytotoxic oligomeric ... -
Trapped in Statelessness: Rohingya Refugees in Bangladesh
(2017-08-21)The Rohingya people are one of the most ill-treated and persecuted refugee groups in the world, having lived in a realm of statelessness for over six generations, and who are still doing so. In recent years, more than ... -
Trauma Affecting Asian-Pacific Islanders in the San Francisco Bay Area
(2017-09-12)Trauma is a transgenerational process that overwhelms the community and the ability of family members to cope with life stressors. An anthropologist trained in ethnographic methods observed three focus groups from a ... -
Trends and Costs Associated With Suboptimal Physical Activity Among US Women With Cardiovascular Disease
(2019-04-12)IMPORTANCE: Cardiovascular disease (CVD) is the leading cause of death and disability among women. Achievement of recommended physical activity (PA) levels is an essential component of CVD management. OBJECTIVE: To ... -
Trends in Dengue Cases Imported into the United States from Pan America 2001–2012
(2015)The objective of this study was to improve risk assessments of travel on dengue (DEN) virus (DENV) distribution. We investigated the exposure risk of US citizens traveling to DEN-endemic Pan American countries. The number ... -
Trial by Fire: On the Terminology and Methods Used in Pyrogenic Organic Carbon Research
(2017-11-17)Our understanding of the cycling of fire-derived, i.e., pyrogenic organic matter (pyOM), as well as the goals of the community of researchers who study it, may be inhibited by the many terms and methods currently used in ... -
Triclosan Disrupts SKN-1/Nrf2- Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells
(2017-10-03)Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis during adulthood. Here, we show that TCS induces toxicity ... -
Triclosan: An Update on Biochemical and Molecular Mechanisms
(2019-05-02)Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in commercial and healthcare products. Items made with TCS include soaps, deodorants, shampoos, cosmetics, textiles, plastics, surgical ... -
Tumor Microenvironment and Metabolism
(2017-12-16)The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. Cancer cells co-exist with infiltrated immune cells, blood vessels, fibroblasts, and other stromal cells in the ... -
Tweeting the meeting: An in-depth analysis of Twitter activity at kidney week 2011
(2012-07-05)In recent years, the American Society of Nephrology (ASN) has increased its efforts to use its annual conference to inform and educate the public about kidney disease. Social media, including Twitter, has been one method ... -
Two Cases of Paradoxical Hidradenitis Suppurativa while on Adalimumab
(2016)Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterized by recurring abscesses, nodules, and fistulas predominantly in the groin and axillae. The association between HS and Crohn’s disease (CD) ... -
Two hits are better than one: Targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
(2012-05-04)Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell ... -
Una adelfa en tierras extrañas emblemática y misoginia en la "Comedia famosa de los guanches de Tenerife y conquista de Canaria
(2017)In his play Los guanches de Tenerife Lope de Vega resorts to one of the emblems included in his friend Hernando de Soto’s Emblemas moralizadas (1599) to dramatize the encounter between Guanches and Spaniards and to represent ... -
Understanding Racial Disparities in Exposure to Traffic-Related Air Pollution: Considering the Spatiotemporal Dynamics of Population Distribution
(2020-02-01)This study investigates the effect of spatiotemporal distributions of racial groups on disparities in exposure to traffic-related air pollution by considering people’s daily movement patterns. Due to human mobility, a ... -
Understanding the Loss of Maternal Care in Avian Brood Parasites Using Preoptic Area Transcriptome Comparisons in Brood Parasitic and Non-parasitic Blackbirds
(2019-02-13)Parental care is critical for offspring survival in many species. However, parental behaviors have been lost in roughly 1% of avian species known as the obligate brood parasites. To shed light on molecular and neurobiological ... -
Unity in defence: honeybee workers exhibit conserved molecular responses to diverse pathogens
(2017-03-02)Background: Organisms typically face infection by diverse pathogens, and hosts are thought to have developed specific responses to each type of pathogen they encounter. The advent of transcriptomics now makes it possible ... -
Universal Design for Learning (UDL) in the Academic Library: A Methodology for Mapping Multiple Means of Representation in Library Tutorials
(2015)Librarians designed a biology tutorial not only to address an assignment, but also to make tutorials more accessible to students with various learning styles. The Science Librarian created the content by using aspects of ... -
Uptake of and resistance to the antibiotic berberine by individual dormant, germinating and outgrowing bacillus spores as monitored by laser tweezers raman spectroscopy
(2015-12-04)Berberine, an alkaloid originally extracted from the plant Coptis chinensis and other herb plants, has been used as a pharmacological substance for many years. The therapeutic effect of berberine has been attributed to ... -
Use of Multifactorial Treatments to Address the Challenge of Translating Experimental Myocardial Infarct Reduction Strategies
(2019-03-15)Myocardial tissue damage that occurs during an ischemic event leads to a spiraling deterioration of cardiac muscle structural and functional integrity. Reperfusion is the only known efficacious strategy and is the most ...