Browsing Open Access by Title
Now showing items 546-565 of 866
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Nestin in immature embryonic neurons affects axon growth cone morphology and Semaphorin3a sensitivity
(2019-05-01)Correct wiring in the neocortex requires that responses to an individual guidance cue vary among neurons in the same location, and within the same neuron over time. Nestin is an atypical intermediate filament expressed ... -
The net effects of medical malpractice tort reform on health insurance losses: the Texas experience
(2017-11-24)In this paper, we examine the influence of medical malpractice tort reform on the level of private health insurance company losses incurred. We employ a natural experiment framework centered on a series of tort reform ... -
Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)
(2011-12-30)BACKGROUND: Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease in ... -
Neuroleptanalgesia for acute abdominal pain: a systematic review
(2019-02-26)Background: Acute abdominal pain (AAP) comprises up to 10% of all emergency department (ED) visits. Current pain management practice is moving toward multi-modal analgesia regimens that decrease opioid use. Objective: ... -
Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner
(2017-11-20)It has been shown that neurons alter the expression of astrocytic metabolic enzymes by secretion of until now unknown molecule(s) into extracellular fluid. Here, we present evidence that neuron-derived transthyretin (TTR) ... -
Nevada desert dust with heavy metals suppresses IgM antibody production
(2018-02-09)Systemic health effects from exposure to a complex natural dust containing heavy metals from the Nellis Dunes Recreation Area (NDRA) near Las Vegas, NV, were evaluated. Several toxicological parameters were examined following ... -
"Never Waste a Good Crisis": An Interview with Mary Mellor
(2018-07-19) -
A new species of Pionothele from Gobabeb, Namibia (Araneae, Mygalomorphae, Nemesiidae)
(2019-06-03)The mygalomorph spider genus Pionothele Purcell, 1902 comprises two nominal species known only from South Africa. We describe here a new species, Pionothele gobabeb sp. n., from Namibia. This new species is currently only ... -
Non-Linear Interactions between Consumers and Flow Determine the Probability of Plant Community Dominance on Maine Rocky Shores
(2013-08-05)Although consumers can strongly influence community recovery from disturbance, few studies have explored the effects of consumer identity and density and how they may vary across abiotic gradients. On rocky shores in Maine, ... -
Non-pegmatitic beryl related to Carboniferous granitic magmatism, Velasco Range, Pampean Province, NW Argentina
(2016)The specialized leuco-monzogranite of the La Chinchilla Stock is a small Carboniferous stock located in the center of the Velasco Range, Pampean Province, La Rioja, Argentina. It is highly evolved and locally F- and ... -
Nonconsumptive effects in a multiple predator system reduce the foraging efficiency of a keystone predator
(2013-08-01)Many studies have demonstrated that the nonconsumptive effect (NCE) of predators on prey traits can alter prey demographics in ways that are just as strong as the consumptive effect (CE) of predators. Less well studied, ... -
(Not so) gently down the stream: River pollution and health in Indonesia
(2018-09-10)Waterborne diseases, often arising from freshwater pollution, are a leading cause of mortality in developing countries. However, data limitations inhibit our understanding of the extent of damage arising from freshwater ... -
NOTCH3 Expression Is Linked to Breast Cancer Seeding and Distant Metastasis
(2018-09-04)Background: Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs. ... -
Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells
(2013-06-12)Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although ... -
Novel Pelagic Iron-Oxidizing Zetaproteobacteria from the Chesapeake Bay Oxic–Anoxic Transition Zone
(2017-07-18)Chemolithotrophic iron-oxidizing bacteria (FeOB) could theoretically inhabit any environment where Fe(II) and O2 (or nitrate) coexist. Until recently, marine Fe-oxidizing Zetaproteobacteria had primarily been observed in ... -
A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women
(2017-03-02)SNP rs7903146 in the Wnt pathway’s TCF7L2 gene is the variant most significantly associ- ated with type 2 diabetes to date, with associations observed across diverse populations. We sought to determine whether variants in ... -
De Novo Transcriptome Assembly and Comparative Analysis Elucidate Complicated Mechanism Regulating Astragalus chrysochlorus Response to Selenium Stimuli
(2015)Astragalus species are medicinal plants that are used in the world for years. Some Astragalus species are known for selenium accumulation and tolerance and one of them is Astragalus chrysochlorus, a secondary selenium ... -
Nuclear progesterone receptors are up-regulated by estrogens in neurons and radial glial progenitors in the brain of zebrafish
(2011-11-30)In rodents, there is increasing evidence that nuclear progesterone receptors are transiently expressed in many regions of the developing brain, notably outside the hypothalamus. This suggests that progesterone and/or its ... -
Nuclear progestin receptor (Pgr) knockouts in zebrafish demonstrate role for Pgr in ovulation but not in rapid non-genomic steroid mediated meiosis resumption
(2015)Progestins, progesterone derivatives, are the most critical signaling steroid for initiating final oocyte maturation (FOM) and ovulation, in order to advance fully-grown immature oocytes to become fertilizable eggs in ...