Browsing Open Access by Title
Now showing items 21-40 of 866
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The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy
(2013-08-24)Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional chemotherapeutic agents and radiation. Therefore, ... -
All's well that begins Wells: Celebrating 60 years of Animal Behaviour and 36 years of research on anuran social behaviour
(2012-12-04)The scientific study of frogs and toads as important systems in behavioural ecology traces its roots to an influential review published in this journal 36 years ago (Wells 1977a, ‘The social behaviour of anuran amphibians’, ... -
Alternative splicing of UCP1 by non-cell-autonomous action of PEMT
(2019-11-08)Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking ... -
Anaerobic utilization of Fe(III)-xenosiderophores among Bacteroides species and the distinct assimilation of Fe(III)- ferrichrome by Bacteroides fragilis within the genus
(2017-08)In this study, we show that Bacteroides species utilize Fe(III)-xenosiderophores as the only source of exogenous iron to support growth under iron-limiting conditions in vitro anaerobically. Bacteroides fragilis was the ... -
Analysis of the B-RAFV600E mutation in cutaneous melanoma patients with occupational sun exposure
(2014)Sun-exposure is one of the risk factors associated with the development of a cutaneous neoplasm. In melanoma, the Ras-Raf-MEK-ERK (MAPK) signaling pathway is constitutively activated through multiple mechanisms, including ... -
Analysis of the Germination of Individual Clostridium sporogenes Spores with and without Germinant Receptors and Cortex-Lytic Enzymes
(2017-10-25)The Gram-positive spore-forming anaerobe Clostridium sporogenes is a significant cause of food spoilage, and it is also used as a surrogate for C. botulinum spores for testing the efficacy of commercial sterilization. C. ... -
Analytical formulas for differential cross sections for ejection of electrons in ionization of water by protons in the PWBA and ECPSSR
(2015)For comparison with measured ionization cross sections as a function of the ejected electrons from water by protons, analytical formulas of the plane-wave Born approximation (PWBA) and the ECPSSR theory – that accounting ... -
Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment
(2017-08-24)Using the principle of antibody-drug conjugates that deliver highly potent cytotoxic agents to cancer cells for cancer therapy, we here report the synthesis of antisense-oligonucleotides (ASO) and thyroid hormone T3 ... -
Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell
(2019-08-26)Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to ... -
Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation
(2019-03-20)Introduction Copperhead envenomation causes local tissue destruction, leading people to seek treatment for the pain and swelling. First-line treatment for the pain is opioid medications. There is rising concern that an ... -
Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations
(2018-04-30)As part of the Heart Healthy Lenoir Project, we developed a practice level intervention to improve blood pressure control. The goal of this study was: (i) to determine if single nucleotide polymorphisms (SNPs) that associate ... -
Applying the Socio-Ecological Model to barriers to implementation of ACL injury prevention programs: A systematic review
(2017-09-28)Background: Preventing anterior cruciate ligament (ACL) injuries is important to avoid long-term adverse health consequences. Identifying barriers to implementation of these prevention programs is crucial to reducing the ... -
Art Images in Holistic Nursing Education
(2017-05-25)Background: Nursing research has concentrated on empirical knowing with little focus on aesthetic knowing. Evidence from the literature suggests that using visual art in nursing education enhances both clinical observation ... -
Article Commentary: Educating Future Environmental Health Professionals
(2015): Future environmental health problems will require a new generation of educated and trained professionals. Efforts to enhance the environmental public health workforce have been promoted by several organizations. While ... -
Assessment of Leaf Area Index of Rice for a Growing Cycle Using Multi-Temporal C-Band PolSAR Datasets
(2019-11-12)C-band polarimetric synthetic aperture radar (PolSAR) data has been previously explored for estimating the leaf area index (LAI) of rice. Although the rice-growing cycle was partially covered in most of the studies, ... -
Assessment of Occupational Noise Exposure among Groundskeepers in North Carolina Public Universities
(2016-05-12)Groundskeepers may have increased risk to noise-induced hearing loss due to the performance of excessively noisy tasks. This study assessed the exposure of groundskeepers to noise in multiple universities and determined ... -
Assessment of Snow Status Changes Using L-HH Temporal-Coherence Components at Mt. Dagu, China
(2015)Multitemporal Phased Array type L-band Synthetic Aperture Radar (PALSAR) horizontally transmitted and horizontally received (HH) coherence data was decomposed into temporal-coherence, spatial-coherence, and thermal noise ... -
Assessment of Spatial Variation of Groundwater Quality in a Mining Basin
(2017-05-15)Assessment of groundwater quality is vital for the sustainable safe use of this inimitable resource. However, describing the overall groundwater quality condition—particularly in a mining basin—is more complicated due ... -
Association Between Health Literacy, Electronic Health Literacy, Disease-Specific Knowledge, and Health-Related Quality of Life Among Adults With Chronic Obstructive Pulmonary Disease: Cross-Sectional Study
(2019-06-06)Background: Despite the relatively high prevalence of low health literacy among individuals living with chronic obstructive pulmonary disease (COPD), limited empirical attention has been paid to the cognitive and health ... -
Association between Spatial Access to Food Outlets, Frequency of Grocery Shopping, and Objectively-Assessed and Self-Reported Fruit and Vegetable Consumption
(2018-12-13)Because supermarkets are a critical part of the community food environment, the purpose of this paper is to examine the association between accessibility to the supermarket where participants were surveyed, frequency of ...