Browsing by Type"Article"
Now showing items 21-40 of 2100
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Acquiring Articles through Unmediated, User-Initiated Pay-Per-View Transactions: An Assessment of Current Practices
(East Carolina University, 2009-12)Depressed economic times often lead libraries to consider new practices, including alternatives to the traditional subscription model. This column discusses a pay-per-view (PPV) model for acquiring journal articles whereby ... -
The Actin Binding Protein, Fesselin, is a Member of the Synaptopodin Family
(East Carolina University, 2008-07)Fesselin is a natively unfolded protein that is abundant in avian smooth muscle. Like many natively unfolded proteins, fesselin has multiple binding partners including actin, myosin, calmodulin and α-actinin. Fesselin ... -
Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway
(2011)Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. ... -
The Activist's Daughter
(East Carolina University, 1997)Appearing in the North Carolina Books column, this article reviews Ellyn Bache's The Activist's Daughter. -
Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation
(2014-10)The PI3K/Akt/mTOR signaling cascade is a key regulatory pathway controlling cell growth and survival, and its dysregulation is a reported feature of B-precursor acute lymphoblastic leukemia (B-pre ALL). Torin-2 is a ... -
Actual neighborhood-level crime predicts body mass index z-score changes in a multi-racial/ethnic sample of children
(2018-09-24)Longitudinal studies are warranted to clarify the influence crime has on health outcomes in children especially children representing multiple racial/ethnic backgrounds. To address this need, the current study examined whether ... -
Acute Adverse Effects of Fine Particulate Air Pollution on Ventricular Repolarization
(2010-07)Background The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood. Objective We examined the effects and time course of exposure to fine particulate matter ≤ 2.5 ... -
Acute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Study
(2011-03)Background: The mechanisms underlying the relationship between particulate matter (PM) air pollution and cardiac disease are not fully understood. Objectives: We examined the effects and time course of exposure to fine ... -
Acute effects of fine particulate air pollution on ST segment height: A longitudinal study
(2010)Background The mechanisms for the relationship between particulate air pollution and cardiac disease are not fully understood. Air pollution-induced myocardial ischemia is one of the potentially important mechanisms. ... -
Acute Modulation of Adipose Tissue Lipolysis by Intravenous Estrogens
(East Carolina University, 2006-12)Objective: The aim of this study was to determine whether intravenous (IV) conjugated estrogens (EST) acutely enhance the suppression of whole-body or regional subcutaneous adipose tissue (SAT) lipolysis by insulin in ... -
Adaptations of Pseudomonas aeruginosa to the Cystic Fibrosis Lung Environment Can Include Deregulation of zwf, Encoding Glucose-6-Phosphate Dehydrogenase
(East Carolina University, 2005-11)Cystic fibrosis (CF) patients are highly susceptible to chronic pulmonary disease caused by mucoid Pseudomonas aeruginosa strains that overproduce the exopolysaccharide alginate. We showed here that a mutation in zwf, ... -
Adaptive evolution of genes underlying schizophrenia
(East Carolina University, 2007-11-22)Schizophrenia poses an evolutionary-genetic paradox because it exhibits strongly negative fitness effects and high heritability, yet it persists at a prevalence of approximately 1% across all human cultures. Recent theory ... -
Adaptive responses to salinity stress across multiple life stages in anuran amphibians
(2017-08-01)Background In many regions, freshwater wetlands are increasing in salinity at rates exceeding historic levels. Some freshwater organisms, like amphibians, may be able to adapt and persist in salt-contaminated wetlands by ... -
Adduction to arginine detoxifies aflatoxin B1 by eliminating genotoxicity and altering in vitro toxicokinetic profiles
(2018-01-12)Aflatoxin B1 (AFB1), a class 1 carcinogen and prominent food contaminant, is highly linked to the development of hepatocellular carcinoma (HCC) and plays a causative role in a large portion of global HCC cases. We have ... -
Adequacy of Maternal Iron Status Protects against Behavioral, Neuroanatomical, and Growth Deficits in Fetal Alcohol Spectrum Disorders
(2012)Fetal alcohol spectrum disorders (FASD) are the leading non-genetic cause of neurodevelopmental disability in children. Although alcohol is clearly teratogenic, environmental factors such as gravidity and socioeconomic ... -
Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice
(2019-04-05)α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species. ... -
Adolescent BMI: The Importance of Intrinsic and Extrinsic Factors
(2018-04-13)Objectives: Research shows that weight trends in adolescence persist into adulthood, but do the same factors contribute to weight in adolescence as in adulthood? Are extrinsic factors presumably more important than ... -
Adolescent smoking: The relationship between cigarette consumption and BMI
(2018-12-07)Background:Studies relating cigarette smoking and body weight yield conflicting results. Weight-lowering effects in women and men have been associated with smoking, however, no effects on weight have been proven.This study ...