Browsing Microbiology and Immunology by Title

Now showing items 70-89 of 100

  • Pseudomonas aeruginosa PqsA Is an Anthranilate-Coenzyme A Ligase 

    Coleman, James P.; Hudson, L. Lynn; McKnight, Susan L.; Farrow, John M. III; Calfee, M. Worth; Lindsey, Claire A.; Pesci, Everett C. (East Carolina University, 2008-02)
    Pseudomonas aeruginosa is an opportunistic human pathogen which relies on several intercellular signaling systems for optimum population density-dependent regulation of virulence genes. The Pseudomonas quinolone signal ...

  • Pseudomonas aeruginosa relA Contributes to Virulence in Drosophila melanogaster 

    Erickson, David L.; Lines, J. Louise; Pesci, Everett C.; Venturi, Vittorio; Storey, Douglas G. (East Carolina University, 2004-10)
    The stringent response is a mechanism by which bacteria adapt to nutritional deficiencies through the production of the guanine nucleotides ppGpp and pppGpp, produced by the RelA enzyme. We investigated the role of the ...

  • The Pseudomonas Quinolone Signal Regulates rhl Quorum Sensing in Pseudomonas aeruginosa 

    McKnight, Susan L.; Iglewski, Barbara H.; Pesci, Everett C. (East Carolina University, 2000-05)
    The opportunistic pathogen Pseudomonas aeruginosa uses intercellular signals to control the density-dependent expression of many virulence factors. The las and rhl quorum-sensing systems function, respectively, through the ...

  • The pseudorabies virus UL28 protein enters the nucleus after coexpression with the herpes simplex virus UL15 protein 

    Koslowski, Kim M.; Shaver, Patti R.; Wang, Xiao-Yang; Tenney, Daniel J.; Pederson, Nels E. (East Carolina University, 1997-12)
    Herpesvirus DNA is packaged into capsids in the nuclei of infected cells in a process requiring at least six viral proteins. Of the proteins required for encapsidation of viral DNA, UL15 and UL28 are the most conserved among ...

  • Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa 

    Pesci, Everett C.; Milbank, Jared B. J.; Pearson, James P.; McKnight, Susan L.; Kende, Andrew S.; Greenberg, E. Peter; Iglewski, Barbara H. (East Carolina University, 1999-09-28)
    Numerous species of bacteria use an elegant regulatory mechanism known as quorum sensing to control the expression of specific genes in a cell-density dependent manner. In Gram-negative bacteria, quorum sensing ...

  • Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection 

    Hamden, Khalief E.; Ford, Patrick W.; Whitman, Audy G.; Dyson, Ossie F.; Cheng, Shi-Yuan; McCubrey, James A.; Akula, Shaw M. (East Carolina University, 2004-12)
    Recombinant green fluorescent protein encoding Kaposi’s sarcoma-associated herpesvirus (rKSHV.152) infection of -estradiol stimulated human foreskin fibroblasts (HFF) or HFF/ B-Raf[FF]:ER (expressing a weaker form of ...

  • Raman spectroscopy: the gateway into tomorrow's virology 

    Lambert, Phelps J.; Whitman, Audy G.; Dyson, Ossie F.; Akula, Shaw M. (East Carolina University, 2006-06-28)
    In the molecular world, researchers act as detectives working hard to unravel the mysteries surrounding cells. One of the researchers' greatest tools in this endeavor has been Raman spectroscopy. Raman spectroscopy is a ...

  • RecA and RadA Proteins of Brucella abortus Do Not Perform Overlapping Protective DNA Repair Functions following Oxidative Burst 

    Roux, Christelle M.; Booth, Natha J.; Bellaire, Bryan H.; Gee, Jason M.; Roop, R. Martin II; Kovach, Michael E.; Tsolis, Renee M.; Elzer, Philip H.; Ennis, Don G. (East Carolina University, 2006-07)
    Very little is known about the role of DNA repair networks in Brucella abortus and its role in pathogenesis. We investigated the roles of RecA protein, DNA repair, and SOS regulation in B. abortus. While recA mutants in ...

  • The Redox-Sensitive Transcriptional Activator OxyR Regulates the Peroxide Response Regulon in the Obligate Anaerobe Bacteroides fragilis 

    Rocha, Edson R.; Owens, Gary Jr; Smith, C. Jeffrey (East Carolina University, 2000-09)
    The peroxide response-inducible genes ahpCF, dps, and katB in the obligate anaerobe Bacteroides fragilis are controlled by the redox-sensitive transcriptional activator OxyR. This is the first functional oxidative ...

  • Regulation of KSHV replication by glycoprotein B: chronicles of a virus and its host 

    Dyson, Ossie F. (East Carolina University, 2011)
    Kaposi's sarcoma-associated herpesvirus (KSHV), the causative agent of three cancers: Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and the plasmablastic form of multicentric Castleman disease (MCD), shares many ...

  • The regulation of anthranilate synthesis for the production of pqs in pseudomonas aeruginosa 

    Knoten, Claire A. (East Carolina University, 2013)
    The ubiquitous bacterium P. aeruginosa is an important human pathogen that causes devastating infections in immunocompromised patients and chronic infections in cystic fibrosis patients. The ability of P. aeruginosa to ...

  • Regulation of Bacteriodes fragilis katB mRNA by oxidative stress and carbon limitation. 

    Rocha, Edson R.; Smith, C. Jeffrey (East Carolina University, 1997-11)
    Regulation of the katB catalase gene in the anaerobic bacterium Bacteroides fragilis was studied. Northern blot hybridization analyses revealed that katB was transcribed as an approximately 1.6-kb monocistronic mRNA. The ...

  • Regulation of Pseudomonas Quinolone Signal Synthesis in Pseudomonas aeruginosa 

    Wade, Dana S.; Calfee, M. Worth; Rocha, Edson R.; Ling, Elizabeth A.; Engstrom, Elana; Coleman, James P.; Pesci, Everett C. (East Carolina University, 2005-07)
    Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in cystic fibrosis patients and is a major source of nosocomial infections. This bacterium controls many virulence factors by using ...

  • Review: Carbon Nanotubes and Chronic Granulomatous Disease 

    Barna, Barbara P.; Judson, Marc A.; Thomassen, Mary Jane (2014-06-23)
    Use of nanomaterials in manufactured consumer products is a rapidly expanding industry and potential toxicities are just beginning to be explored. Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles ...

  • Roles of the RAF/MEK/ERK Pathway in Cell Growth, Malignant Transformation and Drug Resistance 

    McCubrey, James A.; Steelman, Linda S.; Chappell, William H.; Abrams, Stephen L.; Wong, Ellis W.T.; Chang, Fumin; Lehmann, Brian D.; Terrian, David M.; Milella, Michele; Tafuri, Agostino; Stivala, Franca; Libra, Massimo; Basecke, Jorg; Evangelisti, Camilla; Martelli, Alberto M.; Franklin, Richard A. (East Carolina University, 2007-08)
    Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly ...

  • Similarity to peroxisomal-membrane protein family reveals that Sinorhizobium and Brucella BacA affect lipid-A fatty acids 

    Ferguson, Gail P.; Datta, Anup; Baumgartner, John; Roop, R. Martin II; Carlson, Russ W.; Walker, Graham C. (East Carolina University, 2004-04-06)
    Sinorhizobium meliloti, a legume symbiont, and Brucella abortus, a phylogenetically related mammalian pathogen, both require the bacterial-encoded BacA protein to establish chronic intracellular infections in their respective ...

  • Solubility and Bioactivity of the Pseudomonas Quinolone Signal Are Increased by a Pseudomonas aeruginosa-Produced Surfactant 

    Calfee, M. Worth; Shelton, John G.; McCubrey, James A.; Pesci, Everett C. (East Carolina University, 2005-02)
    Pseudomonas aeruginosa is a gram-negative bacterium that causes serious infections in immunocompromised individuals and cystic fibrosis patients. This opportunistic pathogen controls many of its virulence factors and ...

  • Targeting prostate cancer based on signal transduction and cell cycle pathways 

    Lee, John T.; Lehmann, Brian D.; Terrian, David M.; Chappell, William H.; Stivala, Franca; Libra, Massimo; Martelli, Alberto M.; Steelman, Linda S.; McCubrey, James A. (East Carolina University, 2008-06-15)
    Prostate cancer remains a leading cause of death in men despite increased capacity to diagnose at earlier stages. After prostate cancer has become hormone independent, which often occurs after hormonal ablation therapies, ...

  • Targeting the leukemic stem cell: the Holy Grail of leukemia therapy 

    Misaghian, Negin; Ligresti, Giovanni; Steelman, L. S.; Bertrand, Fred E.; Basecke, Jorg; Libra, Massimo; Nicoletti, Ferdinando; Stivala, F.; Milella, Michele; Tafuri, A.; Cervello, Melchiorre; Martelli, Alberto M.; McCubrey, James A. (East Carolina University, 2009-01)
    Since the discovery of leukemic stem cells (LSCs) over a decade ago, many of their critical biological properties have been elucidated, including their distinct replicative properties, cell surface phenotypes, their ...

  • Targeting the RAF/MEK/ERK, PI3K/AKT and P53 pathways in hematopoietic drug resistance 

    McCubrey, James A.; Steelman, Linda S.; Franklin, Richard A.; Abrams, Stephen L.; Chappell, William H.; Wong, Ellis W.T.; Lehmann, Brian D.; Terrian, David M.; Basecke, Jorg; Stivala, Franca; Libra, Massimo; Evangelisti, Camilla; Martelli, Alberto M. (East Carolina University, 2007)