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Oral microbe-host interactions: influence of β-glucans on gene expression of inflammatory cytokines and metabolome profile
(2017-03-07)
Background: The aim of this study was to evaluate the effects of β-glucan on the expression of inflammatory mediators and metabolomic profile of oral cells [keratinocytes (OBA-9) and fibroblasts (HGF-1) in a dual-chamber ...
Nearshore mixing and nutrient delivery along the western Antarctic Peninsula
(2017-10)
The surface waters of the Southern Ocean play a key role in the global climate and carbon cycles by
promoting growth of some of the world’s largest phytoplankton blooms. Several studies have emphasized the
importance of ...
Pathology Informatics Essentials for Residents: A Flexible Informatics Curriculum Linked to Accreditation Council for Graduate Medical Education Milestones
(2017-01)
Context.—Recognition of the importance of informatics to the practice of pathology has surged. Training residents in pathology informatics has been a daunting task for most residency programs in the United States because ...
Una adelfa en tierras extrañas emblemática y misoginia en la "Comedia famosa de los guanches de Tenerife y conquista de Canaria
(2017)
In his play Los guanches de Tenerife Lope de Vega resorts to one of the emblems included in his friend Hernando de Soto’s Emblemas moralizadas (1599) to dramatize the encounter between Guanches and Spaniards and to represent ...
Species-Specific Conservation of Linear Antigenic Sites on Vaccinia Virus A27 Protein Homologs of Orthopoxviruses
(2019-05-29)
The vaccinia virus (VACV) A27 protein and its homologs, which are found in a large number of members of the genus Orthopoxvirus (OPXV), are targets of viral neutralization by host antibodies. We have mapped six binding ...
Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes
(2019-03-21)
The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we ...
The concept of essential use for determining when uses of PFASs can be phased out
(2019-05-27)
Because of the extreme persistence of per- and polyfluoroalkyl substances (PFASs) and their associated risks, the Madrid Statement argues for stopping their use where they are deemed not essential or when safer alternatives ...
STepped exercise program for patients with knee OsteoArthritis (STEP-KOA): protocol for a randomized controlled trial
(2019-05-28)
Background:
Physical therapy (PT) and other exercise-based interventions are core components of care for knee osteoarthritis (OA), but both are underutilized, and some patients have limited access to PT services. This ...
Structural insights into flagellar stator– rotor interactions
(2019-07-17)
The bacterial flagellar motor is a molecular machine that can rotate the flagellar
filament at high speed. The rotation is generated by the stator–rotor interaction, coupled with an
ion flux through the torque-generating ...
Specialized High‐Protein Oral Nutrition Supplement Improves Home Nutrient Intake of Malnourished Older Adults Without Decreasing Usual Food Intake
(2018-11-22)
Background: Reduced nutrient intake is common in patients after hospitalization, contributing to increased risk for readmissionand mortality. Oral nutrition supplements can improve nutrition status and clinical outcomes, ...