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Now showing items 571-580 of 991
N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs
(2017-09)
Post-transcriptional regulation of mRNA during oxygen deprivation, or hypoxia, can affect the survivability of cells. Hypoxia has been shown to increase stability of a subset of ischemia-related mRNAs, including VEGF. RNA ...
Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner
(2017-11-20)
It has been shown that neurons alter the expression of astrocytic metabolic enzymes by secretion of until now unknown molecule(s) into extracellular fluid. Here, we present evidence that neuron-derived transthyretin (TTR) ...
PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines
(2017-02-20)
B-acute lymphoblastic leukemia (B-ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. Philadelphia chromosome-positive (Ph+) B-ALL is a subtype that expresses the Bcr-Abl fusion ...
Molecular targeting of the Aurora-A/SMAD5 oncogenic axis restores chemosensitivity in human breast cancer cells
(2017-09-01)
Although the majority of breast cancers initially respond to the cytotoxic effects of chemotherapeutic agents, most breast cancer patients experience tumor relapse and ultimately die because of drug resistance. Breast ...
Ml proteins from Mesorhizobium loti and MucR from Brucella abortus: an AT-rich core DNA-target site and oligomerization ability
(2017-11-17)
Mesorhizobium loti contains ten genes coding for proteins sharing high amino acid sequence identity with members of the Ros/MucR transcription factor family. Five of these Ros/MucR family members from Mesorhizobium loti ...
Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females
(2017-01-26)
Background and Purpose
Irisin is an exercise-responsive myokine that has been proposed to exert anti-obesity bene- fits; yet its response during exercise in obese women is not described. This study character- ized plasma ...
Pineal Region Glioblastoma, a Case Report and Literature Review
(2017-06-12)
Introduction: Pineal region glioblastoma multiforme (GBM) is a rare disease entity with a generally poor prognosis. We present a case of a patient with an unresectable pineal region GBM treated with chemoradiation with ...
Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
(2017-02)
Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 ...
RhoGTPase Regulators Orchestrate Distinct Stages of Synaptic Development
(2017-01-23)
Small RhoGTPases regulate changes in post-synaptic spine morphology and density that support learning and memory. They are also major targets of synaptic disorders, including Autism. Here we sought to determine whether ...
Rho GTPases as therapeutic targets in Alzheimer’s disease
(2017-12-15)
The progress we have made in understanding Alzheimer’s disease (AD) pathogenesis has led to the identification of several novel pathways and potential therapeutic targets. Rho GTPases have been implicated as critical ...