Browsing Health Sciences Campus by Author "Dohm, G. Lynis"
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Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats.
Dolan, Patricia L.; Tapscott, Edward B.; Dorton, Peter J.; Dohm, G. Lynis (East Carolina University, 1993-01-15)Both insulin and contraction stimulate glucose transport in skeletal muscle. Insulin-stimulated glucose transport is decreased in obese humans and rats. The aims of this study were (1) to determine if contraction-stimulated ... -
Diabetes: Have we got it all wrong? Hyperinsulinism as the culprit: Surgery provides the evidence
Pories, Walter J.; Dohm, G. Lynis (2012-12) -
The effect of fasting on the activation in vivo of the insulin receptor kinase.
Contreras, Ivan; Dohm, G. Lynis; Abdallah, Silvia; Wells, James A.; Mooney, Nitin; Rovira, Adela; Caro, Jose F. (East Carolina University, 1990-02-01)Fasting causes insulin resistance in liver and fat, and increases insulin sensitivity in muscle. We studied the response in vitro and in vivo to insulin of the insulin receptor tyrosine kinase in muscle and liver from 72 ... -
An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
Dohm, G. Lynis; Tapscott, Edward B.; Pories, Walter J.; Dabbs, David J.; Flickinger, Edward G.; Meelheim, Diane; Fushiki, Tohru; Atkinson, Samuel M.; Elton, Charles W.; Caro, Jose F. (East Carolina University, 1988-08)We have developed an in vitro muscle preparation suitable for metabolic studies with human muscle tissue and have investigated the effects of obesity and non-insulin-dependent diabetes mellitus (NIDDM) on glucose transport. ... -
Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.
Kern, Marialice; Wells, James A.; Stephens, Jacqueline M.; Elton, Charles W.; Friedman, Jacob E.; Tapscott, Edward B.; Pekala, Phillip H.; Dohm, G. Lynis (East Carolina University, 1990-09-01)Glucose transport in skeletal muscle is mediated by two distinct transporter isoforms, designated muscle/adipose glucose transporter (Glut4) and erythrocyte/HepG2/brain glucose transporter (Glutl), which differ in both ... -
Is there a metabolic program in the skeletal muscle of obese individuals?
Houmard, Joseph A.; Pories, Walter J.; Dohm, G. Lynis (2011-04-26)Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are ... -
Is type II diabetes mellitus (NIDDM) a surgical disease?
Pories, Walter J.; MacDonald, Kenneth G. Jr.; Flickinger, Edward G.; Dohm, G. Lynis; Sinha, Madhur K.; Barakat, Hisham A.; May, Harold J.; Khazanie, Prabhaker; Swanson, Melvin S.; Morgan, Elizabeth J.; Leggett-Frazier, Nancy; Long, Stuart D.; Brown, Brenda M.; O'Brien, Kevin F.; Caro, Jose F. (East Carolina University, 1992-06)Since February 1, 1980, 515 morbidly obese patients have undergone the Greenville gastric bypass (GGB) operation. Of these, 212 (41.2%) were euglycemic, 288 (55.9%) were either diabetic or had glucose intolerance, and ... -
Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery
Bikman, Benjamin Thomas; Zheng, Donghai; Pories, Walter J.; Chapman, William H. H.; Pender, John R.; Bowden, Rita C.; Reed, Melissa A.; Cortright, Ronald N.; Tapscott, Edward B.; Houmard, Joseph A.; Tanner, Charles J.; Lee, Jihyun; Dohm, G. Lynis (East Carolina University, 2008-12)Context: Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity. Objective: The aim of the study was to investigate the effects of gastric bypass surgery and the ... -
Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK Action in a Fiber-Type Specific Manner
Bikman, Benjamin Thomas; Zheng, Donghai; Kane, Daniel A.; Anderson, Ethan; Woodlief, Tracey L.; Price, Jesse W.; Dohm, G. Lynis; Neufer, P. Darrell; Cortright, Ronald N. (2010)Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) ... -
Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.
Friedman, Jacob E.; Dohm, G. Lynis; Leggett-Frazier, Nancy; Elton, Charles W.; Tapscott, Edward B.; Pories, Walter J.; Caro, Jose F. (East Carolina University, 1992-02)A major defect contributing to impaired insulin action in human obesity is reduced glucose transport activity in skeletal muscle. This study was designed to determine whether the improvement in whole body glucose disposal ... -
Stimulation of glucose uptake by insulin-like growth factor II in human muscle is not mediated by the insulin-like growth factor II/mannose 6-phosphate receptor.
Burguera, Bartolome; Elton, Charles W.; Tapscott, Edward B.; Pories, Walter J.; Dimarchi, Richard; Sakano, Katsu-ichi; Dohm, G. Lynis (East Carolina University, 1994-06-15)Although the growth-promoting effects of insulin-like growth factor II (IGF-II) have been intensively studied, the acute actions of this hormone on glucose metabolism have been less well evaluated, especially in skeletal ... -
Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome
Seridi, Loqmane; Leo, Gregory C.; Dohm, G. Lynis; Pories, Walter J.; Lenhard, James (2018-05-31)Roux-en-Y gastric bypass (RYGB) is an effective way to lose weight and reverse type 2 dia- betes. We profiled the metabolome of 18 obese patients (nine euglycemic and nine diabet- ics) that underwent RYGB surgery and seven ... -
Type 2 Diabetes Modifies Skeletal Muscle Gene Expression Response to Gastric Bypass Surgery
Dohm, G. Lynis; Barberio, Matthew D.; Pories, Walter J.; Gadaleta, Natalie A.; Houmard, Joseph A.; Nadler, Evan P.; Hubal, Monica J. (2021-10-06) -
Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus.
Pories, Walter J.; Swanson, Melvin S.; MacDonald, Kenneth G. Jr.; Long, Stuart B.; Morris, Patricia G.; Brown, Brenda M.; Barakat, Hisham A.; deRamon, Richard A.; Israel, R. Gay; Dolezal, Jeanette M.; Dohm, G. Lynis (East Carolina University, 1995-09)OBJECTIVE: This report documents that the gastric bypass operation provides long-term control for obesity and diabetes. SUMMARY BACKGROUND DATA: Obesity and diabetes, both notoriously resistant to medical therapy, continue ...