Browsing by Author "Yang, Li V."
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Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
Justus, Calvin R.; Dong, Lixue; Yang, Li V. (2013-10)The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ... -
Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells
Dong, Lixue; Krewson, Elizabeth A.; Yang, Li V. (2017-01-27)Acidosis commonly exists in the tissue microenvironment of various pathophysiological conditions such as tumors, inflammation, ischemia, metabolic disease, and respiratory disease. For instance, the tumor microenvironment ... -
Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis
Dong, Lixue; Li, Zhigang; Leffler, Nancy R.; Asch, Adam S.; Chi, Jen-Tsan; Yang, Li V. (2013)Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic organs, sickle cell disease, and many other pathological conditions due to hypoxia, glycolytic cell metabolism and deficient blood ... -
Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8
Li, Zhigang; Dong, Lixue; Dean, Eric; Yang, Li V. (2013-10)Acidosis is a biochemical hallmark of the tumor microenvironment. Here, we report that acute acidosis decreases c-Myc oncogene expression in U937 human lymphoma cells. The level of c-Myc transcripts, but not mRNA or protein ... -
Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway
Chen, Aishe; Dong, Lixue; Leffler, Nancy R.; Asch, Adam S.; Witte, Owen N.; Yang, Li V. (2011)Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. ... -
Activation of GPR4 by acidosis inhibits tumor cell migration, invasion and metastasis.
Castellone, Reid David (East Carolina University, 2011)Melanoma and Prostate Cancer are two of the most diagnosed forms of cancer in the United States. The ability to metastasize and colonize in a distant location is one of the most devastating hallmarks of cancer as modes ... -
Can GPR4 Be a Potential Therapeutic Target for COVID-19?
Yang, Li V.; Oppelt, Karen A.; Thomassen, Mary Jane; Marie, Mona A.; Nik Akhtar, Shayan; McCallen, Justin D. (2021-01-21) -
Comparison Study of Distinguishing Cancerous and Normal Prostate Epithelial Cells by Confocal and Polarization Diffraction Imaging
Lu, Jun Qing; Jiang, Wenhuan; Yang, Li V.; Ding, Junhua; Hu, Xin-Hua (2016-11-30) -
Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies
Justus, Calvin R.; Sanderlin, Edward J.; Dong, Lixue; Sun, Tianai; Chi, Jen-Tsan; Lertpiriyapong, Kvin; Yang, Li V. (2017-12)Background: Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progres‐ ... -
Emerging roles for the pH-sensing G protein-coupled receptors in response to acidotic stress
Sanderlin, Edward J; Justus, Calvin R.; Krewson, Elizabeth A.; Yang, Li V. (2015)Protons (hydrogen ions) are the simplest form of ions universally produced by cellular metabolism including aerobic respiration and glycolysis. Export of protons out of cells by a number of acid transporters is essential ... -
Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
Naqash, Abdul Rafeh; Appah, Ebenezer; Yang, Li V.; Muzaffar, Mahvish; Marie, Mona A.; Mccallen, Justin D.; Macherla, Shravanti; Liles, Darla; Walker, Paul R. (2019-07-05)Background Compared to conventional chemotherapy, Immune checkpoint inhibitors (ICI) are known to have a distinct toxicity profile commonly identified as immune-related adverse events (irAEs). These irAEs that are believed ... -
Label-free classification of cultured cells through diffraction imaging
Dong, Ke; Feng, Yuanming; Jacobs, Kenneth M.; Lu, Jun Q.; Brock, R. Scott; Yang, Li V.; Bertrand, Fred E.; Farwell, Mary A.; Hu, Xin-Hua (2011-05)Automated classification of biological cells according to their 3D morphology is highly desired in a flow cytometer setting. We have investigated this possibility experimentally and numerically using a diffraction imaging ... -
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
Justus, Calvin R.; Sanderlin, Edward J.; Yang, Li V. (2015-05)Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly ... -
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
Calvin, Justin R.; Sanderlin, Edward J.; Yang, Li V. (2015)Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly ... -
The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells
Krewson, Elizabeth A.; Sanderlin, Edward J.; Marie, Mona A.; Akhtar, Shayan Nik; Velcicky, Juraj; Loetscher, Pius; Yang, Li V. (2020-02-21)be activated by protons in the inflamed tissue microenvironment. Herein, we report that acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelialcells through the ... -
Quantitative Analysis and Comparison of 3D Morphology Between Viable and Apoptotic MCF-7 Breast Cancer Cells and Characterization of Nuclear Fragmentation
Lu, Jun Qing; Chen, Zhan; Ables, Elizabeth Tweedie; Scemama, Jean-Luc; Yang, Li V.; Hu, Xin-Hua (2017-09-08) -
Quantitative analysis and comparison of 3D morphology between viable and apoptotic MCF-7 breast cancer cells and characterization of nuclear fragmentation
Wen, Yuhua; Chen, Zhan; Lu, Jianfen; Ables, Elizabeth Tweedie; Scemama, Jean-Luc; Yang, Li V.; Lu, Jun Q.; Hu, Xin-Hua (2017-09-08)Morphological changes in apoptotic cells provide essential markers for defining and detec- tion of apoptosis as a fundamental mechanism of cell death. Among these changes, the nuclear fragmentation and condensation have ... -
Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
McCubrey, James A.; Fitzgerald, Timothy L.; Yang, Li V.; Lertpiriyapong, Kvin; Steelman, Linda S.; Abrams, Stephen L.; Montalto, Giuseppe; Cervello, Melchiorre; Neri, Luca M.; Cocco, Lucio; Martelli, Alberto M.; Laidler, Piotr; Dulińska-Litewka, Joanna; Rakus, Dariusz; Gizak, Agnieszka; Nicoletti, Ferdinando; Falzone, Luca; Candido, Saverio; Libra, Massimo (2017-02)Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 ... -
Tumor Microenvironment and Metabolism
Yang, Li V. (2017-12-16)The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. Cancer cells co-exist with infiltrated immune cells, blood vessels, fibroblasts, and other stromal cells in the ...