Browsing Brody School of Medicine by Title
Now showing items 173-192 of 431
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A germline-specific isoform of eIF4E (IFE-1) is required for efficient translation of stored mRNAs and maturation of both oocytes and sperm
(East Carolina University, 2009-05-15)Fertility and embryonic viability are measures of efficient germ cell growth and development. During oogenesis and spermatogenesis, new proteins are required for both mitotic expansion and differentiation. Qualitative and ... -
The Global Carbon Metabolism Regulator Crc Is a Component of a Signal Transduction Pathway Required for Biofilm Development by Pseudomonas aeruginosa
(East Carolina University, 2000-01)The transition from a planktonic (free-swimming) existence to growth attached to a surface in a biofilm occurs in response to environmental factors, including the availability of nutrients. We show that the catabolite ... -
Glycemic Control Patterns and Kidney Disease Progression among Primary Care Patients with Diabetes Mellitus
(2011-07)Background: Reducing glycosylated hemoglobin (HbA1c) to near or less than 7% in patients with diabetes is associated with diminished microvascular complications, but this level is not consistently achieved. The purpose of ... -
Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8
(2012)We describe a unique case of Granulocytic Sarcoma (GS) in a male, who presented to us with a painless right breast mass without any prior history of Leukemia. GS is an extramedullary tumor of myeloproliferative precursors ... -
Guidelines for Healthy Foods and Beverages at Company-Sponsored Events. Vendor Tool Kit. Event Planner Tool Kit
(2012-01-25)Vidant Heatlh adopted a "healthy food environment" policy in 2012. This vendor tool kit includes the policy, definitions that support the policy, stept that help a vendor adhere to the policy and resources. Topics covered ... -
Healthy Hospital Food Environment: Policy & Programs in Practice
(2012-05-07)This invited presentation highlights the state of weight at Vidant Health, a health care system serving 29 counties in eastern North Carolina and its innovative Health Food Environment program. A policy, effective in 2012, ... -
Healthy Hospital Food Environment: the PCMH Story.
(2006)This paper describes Pitt Memorial Hospital's response to the call to become a healthy worksite. It describes the hospital's effots to partner in the North Carolina Plan to Prevent Overweight and Obesity and Related Chronic ... -
The heart healthy lenoir project-an intervention to reduce disparities in hypertension control: study protocol
(2013)Background Racial disparities in blood pressure control are well established; however the impact of low health literacy (LHL) on blood pressure has garnered less attention. Office based interventions that are created with ... -
Helping Hands: A Guidebook for Volunteer Meal Providers
(2011-09-27)Helping Hands: A Guidebook for Volunteer Meal Providers Author(s): J. Jennings,1 R. Ward,2 K. Kolasa3; 1Nutrition Science, East Carolina University, Greenville, NC, 2East Carolina University, Greenville, NC, 3Family ... -
How Sweet It Is: Traditional Sweet Iced Tea and the Diabesity Epidemic.
(2015-01)In this paper we present four cases from our medical practice to increase awareness of the role of sweet tea in obesity and diabetes management. We start with a history of Southern style “sweet tea”, and discuss the ... -
Human antibodies for immunotherapy development generated via a human B cell hybridoma technology
(East Carolina University, 2006-03-07)Current strategies for the production of therapeutic mAbs include the use of mammalian cell systems to recombinantly produce Abs derived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage ... -
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
(East Carolina University, 2007-02)The complex human T-cell leukemia virus type 1 (HTLV-1) retrovirus encodes several proteins that are unique to the virus within its 3 -end region. Among them, the viral transactivator Tax and posttranscriptional regulator ... -
Human T-cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) Interacts and Inhibits the Acetyltransferase Activity of Multiple Cellular Coactivator Families to Deregulate Transcription
(East Carolina University, 1/13/16)Of the 20 million individuals infected worldwide with the complex retrovirus, Human T-cell Leukemia Virus Type 1, 5% will develop an incurable and fatal form of leukemia known as adult T-cell leukemia (ATL). During the ... -
HuR binds to a single site on the C/EBP - beta mRNA of 3T3-L1 Adipocytes
(East Carolina University, 2007-03-30)HuR is a ligand for nuclear mRNAs containing adenylate-uridylate rich elements in the 3'- untranslated region. Once bound to the mRNA, HuR is recognized by adapter proteins which then facilitate nuclear export of the ... -
HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype
(East Carolina University, 2009-05-29)In the nucleus HuR binds to mRNAs containing adenylate-uridylate rich elements in the 3?- untranslated region. HuR may influence expression of its ligand mRNA through regulation of polyadenylation, translocation of the ... -
Hyaluronan Oligosaccharides Inhibit Tumorigenicity of Osteosarcoma Cell Lines MG-63 and LM-8 in Vitro and in Vivo via Perturbation of Hyaluronan-Rich Pericellular Matrix of the Cells
(East Carolina University, 2007-07)Numerous studies have demonstrated a correlation between hyaluronan expression and the malignant properties of various kinds of cancer , and inhibition of hyaluronan production causes decreased tumor growth. Hyaluronan ... -
Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies.
(East Carolina University, 1997-03)The reactive airways dysfunction syndrome (RADS), the reactive upper airways dysfunction syndrome (RUDS), the sick building syndrome (SBS), and the multiple chemical sensitivity syndrome (MCS) are overlapping disorders ... -
Hypoxic Conditioned Medium from Rat Cerebral Cortical Cells Enhances the Proliferation and Differentiation of Neural Stem Cells Mainly through PI3-K/Akt Pathways
(2014)Purpose To investigate the effects of hypoxic conditioned media from rat cerebral cortical cells on the proliferation and differentiation of neural stem cells (NSCs) in vitro, and to study the roles of PI3-K/Akt and JNK ... -
Identification and Characterization of alcR, a Gene Encoding an AraC-Like Regulator of Alcaligin Siderophore Biosynthesis and Transport in Bordetella pertussis and Bordetella bronchiseptica
(East Carolina University, 1998-02)A Bordetella bronchiseptica iron transport mutant was isolated following an enrichment procedure based on streptonigrin resistance. The mutant displayed a growth defect on iron-restricted medium containing ferric alcaligin ... -
Identification and characterization of iron-regulated Bordetella pertussis alcaligin siderophore biosynthesis genes.
(East Carolina University, 1996-08)Bordetella bronchiseptica mutants BRM1, BRM6, and BRM9 fail to produce the native dihydroxamate siderophore alcaligin. A 4.5-kb BamHI-SmaI Bordetella pertussis genomic DNA fragment carried multiple genes required to restore ...