Browsing Open Access by Title
Now showing items 390-409 of 866
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Horizontal gene transfer of epigenetic machinery and evolution of parasitism in the malaria parasite Plasmodium falciparum and other apicomplexans
(2013-02-11)The acquisition of complex transcriptional regulatory abilities and epigenetic machinery facilitated the transition of the ancestor of apicomplexans from a free-living organism to an obligate parasite. The ability to control ... -
Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion
(2019-06)Fibrinogen is an essential part of the blood coagulation cascade and a major component of the extracellular matrix in mammals. The interface between fibrinogen and bacterial pathogens is an important determinant of the ... -
How many steps/day are enough? For older adults and special populations
(2011-07-28)Older adults and special populations (living with disability and/or chronic illness that may limit mobility and/or physical endurance) can benefit from practicing a more physically active lifestyle, typically by increasing ... -
How Pre-tenure and Tenured Faculty Can Engage Undergraduates in Publishable Research
(2019-02-06)Differences in career stage may influence work stress and job satisfaction (Olsen and Crawford, 1998), which in turn can impact attitudes about recruiting, managing, and mentoring undergraduates in publishable research ... -
HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I
(2019-06-28)Adult T-cell Leukemia (ATL) is a lymphoproliferative disease of CD4+ T-cells infected with Human T-cell Leukemia Virus type I (HTLV-1). With the exception of allogeneic hematopoietic stem cell transplantation, there are ... -
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP
(2012-03-19)The homologous cellular coactivators p300 and CBP contain intrinsic lysine acetyl transferase (termed HAT) activity. This activity is responsible for acetylation of several sites on the histones as well as modification of ... -
A Hydroclimatological Analysis of Precipitation in the Ganges–Brahmaputra–Meghna River Basin
(2018-09-29)Understanding seasonal precipitation input into river basins is important for linking large-scale climate drivers with societal water resources and the occurrence of hydrologic hazards such as floods and riverbank erosion. ... -
Hypoxia and Hypoglycemia synergistically regulate mRNA stability
(2017-07)Ischemic events, common in many diseases, result from decreased blood flow and impaired delivery of oxygen and glucose to tissues of the body. While much is known about the cellular transcriptional response to ischemia, ... -
Hypoxia inducible factor-1α-dependent epithelial to mesenchymal transition under hypoxic conditions in prostate cancer cells
(2016)Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death. Hypoxia is an environmental stimulus that plays an important role in the development and cancer progression ... -
"I am still negative": Female sex workers' perspectives on uptake and use of daily pre-exposure prophylaxis for HIV prevention in South Africa.
(2019-04)Women remain highly vulnerable to HIV infection in sub-Saharan Africa, with female sex workers (FSWs) facing some of the highest rates of HIV. Oral pre-exposure prophylaxis (PrEP) has the potential to reduce new infections ... -
"I Thought You Loved Me too?": Outcomes of Discrepant Involvement in Romantic Relationships
(2018-12-21)As romantic relationships begin and evolve, it is sometimes the case that partners are discrepant in their attraction to, love for, and commitment to each other. Data were collected from 460 undergraduates who completed ... -
Identification of Vape Shops in Two North Carolina Counties: An Approach for States without Retailer Licensing
(2016-10-27)Stores that sell electronic nicotine delivery systems (ENDS) as their primary product are a new phenomenon and often termed “vape shops”. While vape shops are now regulated by state and federal agencies, not all states ... -
Identifying Keys to Success in Innovative Teaching: Student Engagement and Instructional Practices as Predictors of Student Learning in a Course Using a Team- Based Learning Approach
(2017-09)When implementing innovative teaching techniques, instructors often seek to gauge the success of their methods. Proposing one approach to assessing classroom innovation, this study examines the ability of students’ ratings ... -
Identifying Lesbian, Gay, Bisexual, and Transgender Search Terminology: A Systematic Review of Health Systematic Reviews
(2016-05-24)Research on the health of lesbian, gay, bisexual, and transgender (LGBT) populations can provide important information to address existing health inequalities. Finding existing research in LGBT health can prove challenging ... -
IFN-β Facilitates Neuroantigen-Dependent Induction of CD25+ FOXP3+ Regulatory T Cells That Suppress Experimental Autoimmune Encephalomyelitis
(2016-10-15)This study introduces a flexible format for tolerogenic vaccination that incorporates IFN-β and neuroantigen (NAg) in the Alum adjuvant. Tolerogenic vaccination required all three components, IFN-β, NAg, and Alum, for ... -
Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture
(2012-01-04)Polybrominated diphenyl ethers (PBDEs) are an important class of flame-retardants that are environmentally persistent and bioaccumulative. Toxicity of these compounds has become a concern because detectable levels of PBDEs ... -
Impact of a Revised Curriculum Focusing on Clinical Neurology and Musculoskeletal Care on a Required Fourth-Year Medical Student Physical Medicine and Rehabilitation Clerkship
(2016-11-29)Background. A Required Fourth-Year Medical Student Physical Medicine and Rehabilitation (PM&R) Clerkship was found to increase students' knowledge of PM&R; however the students' overall rotation evaluations were consistently ... -
Impact of body mass index on the incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis
(2019-03-12)Background: Pancreatitis is a potential major complication after endoscopic retrograde cholangiopancreatography (post-ERCP pancreatitis; PEP). Obesity has been associated with increased severity of acute pancreatitis. ...